1. The Rebuke of Hypocrisy
45 One of the lawyers answered him, “Teacher, in saying these things you insult us also.” 46 And he said, “Woe to you lawyers also! For you load people with burdens hard to bear, and you yourselves do not touch the burdens with one of your fingers. Luke 11:45-46 (ESV)

The implication of Jesus’ statement is that the scribes purposely made the laws difficult to follow in order to bring about moral failure in others.  (Chuck Swindoll)

8 “Remember the Sabbath day, to keep it holy. 9 Six days you shall labor, and do all your work, 10 but the seventh day is a Sabbath to the LORD your God. On it you shall not do any work, Exodus 20:8-10 (ESV)

28 Come to me, all who labor and are heavy laden, and I will give you rest. 29 Take my yoke upon you, and learn from me, for I am gentle and lowly in heart, and you will find rest for your souls. 30 For my yoke is easy, and my burden is light.” Matthew 11:28-30 (ESV)

2. The Rebuke of Rejecting God’s Messengers
47 Woe to you! For you build the tombs of the prophets whom your fathers killed. 48 So you are witnesses and you consent to the deeds of your fathers, for they killed them, and you build their tombs. 49 Therefore also the Wisdom of God said, ‘I will send them prophets and apostles, some of whom they will kill and persecute,’ 50 so that the blood of all the prophets, shed from the foundation of the world, may be charged against this generation, 51 from the blood of Abel to the blood of Zechariah, who perished between the altar and the sanctuary. Yes, I tell you, it will be required of this generation. Luke 11:47-51 (ESV)

Abel and Zechariah were the first and last martyrs in the Hebrew Old Testament.

The way these individuals treated the prophets and apostles associated with Jesus would prove what kind of men the scribes really were. (Kent Hughes)

3.The Rebuke of False Teaching
52 Woe to you lawyers! For you have taken away the key of knowledge. You did not enter yourselves, and you hindered those who were entering.” 53 As he went away from there, the scribes and the Pharisees began to press him hard and to provoke him to speak about many things, 54 lying in wait for him, to catch him in something he might say. Luke 11:52-54 (ESV)

The key of knowledge that provides salvation is none other than Jesus Christ. (Philip Ryken)

Do your best to present yourself to God as one approved, a worker who has no need to be ashamed, rightly handling the word of truth. 2 Timothy 2:15 (ESV)

5 And I said: “Woe is me! For I am lost; for I am a man of unclean lips, and I dwell in the midst of a people of unclean lips; for my eyes have seen the King, the LORD of hosts!” Isaiah 6:5 (ESV)